Can 5-FU Dissolve Radiesse Generated Volume from Years Ago?

5FU has inherent risks and has not been studied to address residual volume from Radiesse facial fillers.  An examination can provide you with more specific and suitable options. Raffy Karamanoukian, Los Angeles

5-FU works well to soften scar tissue and prevent further formation, though it works best before scar maturation.  It's a reasonable treatment option to treat focal areas of scarring.    

5-Fluorouracil may be helpful for scars, but less so for excess volume from Radiesse. Your Radiesse injection was years ago, and most likely the excess volume you are trying to reduce with 5-FU is not so much given by the Radiesse any more. 

 The Radiesse injected years ago has long since been absorbed.  If you believe that you have residual scar tissue left from the material, this might be tried with caution as to how successful it might be in decreasing the volume.

I have used 5-FU on scars and I have tried it on Radiesse. It should not be compared to a hyaluronidase which actually does dissolve HA fillers. 5-FU has minimal results on Radiesse. I wouldn't call it a success by any means, but you can have a small amount of improvement.