Hi beckaroo1, thank you for your excellent question. Juvéderm and Restylane, which are hyaluronic acid based fillers, are excellent choices to be used peri-orally. The oral commissures (corners of the mouth) are strategically targeted with fillers to bring up drooping corners of the mouth. Also product can be placed in the area of marionette lines to offer additional support in the area. Interestingly, if you have any midface volume loss, using Voluma (a more viscous filler with "lifting" ability) in the cheeks can also help bring up the corners of the month, in addition to softening nasolabial folds. I would also consider a neurotoxin (e.g. Botox) which can be placed in the lip depressor muscles to help relax and lift the mouth. A synergistic approach is best! Best of luck, Dr. K