Collagen is produced by cells in the skin called fibroblasts, so procedures that stimulate these cells are the most effective. As injections are typically used to go more deeply below the skin, they are not as effective in plumping the skin or improving melasma which is due to pigmentation in the upper layers. Microneedling is ideal for allowing penetration of treatment serums directly at the level where they will do the most good. Interestingly, studies are now showing that shorter needle lengths are more effective than longer needle lengths for creating channels that allow for better penetration of topical serums and medications. Longer needles create more tissue damage, swelling and bleeding which can adversely affect penetration of these serums. A published scientific study showed a significantly greater penetration of serum applied after microneedling with 0.5 mm needles vs 1.5 mm needles. Plus, we are also seeing better results using human growth-factor serums than with PRP.
In my office, we use the ProCell Therapies system which combines motorized micro-needling with concentrated human growth factor serums made from human stem cells.
Microneedling treatments can also be safely done at home with a new treatment kit from Célage Bioscience which uses a growth-factor serum derived from human bone marrow mesenchymal stem cells with a hand-held microneedling stamping tool with 0.25 mm needles.