Introduction to: Current Aesthetic Use of AbobotulinumtoxinA (Dysport) in Clinical Practice An Evidence-Based Consensus Review

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The field of cosmetic medicine continues to develop because of our desire to provide safe, predictable, aesthetic results for our patients. This supplement is a valuable and practical resource for well-trained aesthetic practitioners who administer botulinum neurotoxin type A (BoNT-A). In addition, it allows the provider to better understand the clinically-relevant details of the current aesthetic applications of abobotulinumtoxinA (Dysport; Medicis Aesthetics, Inc, Scottsdale, Arizona). This neurotoxin only became available in the United States in 2009; prior to that, onabotulinumtoxinA (Botox; Allergan, Inc, Irvine, California) had been the only available neuromodulator for approved aesthetic use (since 2002). An update on its use as it compares with the other available toxins is timely and clinically relevant.
This supplement offers both an invaluable systematic literature review of the evidence on reconstitution and handling, the field of effect, neutralizing antibodies, treatment of specific anatomic areas, and combination of BoNT-A with other aesthetic therapies, as well as a summary of current clinical practices from 13 experts in the fields of plastic surgery, facial plastic surgery, and dermatology. It is important to note that the committee achieved consensus on most issues, but the details of their nonconsensus opinions are also detailed.
Without combining evidence-based literature and clinical experience, we would never grow in this field. The expert opinions presented in this supplement provide the reader with a practical guide for the 3 Food and Drug Administration–approved BoNT-A products. After reading this supplement, I believe clinicians will better understand all of the current potential applications, both on-label and off-label, of these products—and they will have gained a better perspective on the science behind their development and approval process. I congratulate this group for providing a systematic review of the evidence for the safe use of neurotoxins while providing valuable clinically relevant information in a practical format.
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Chicago Plastic Surgeon