Juvederm: Stories

Please see article re: reactions to dermal fillers (chemically modified versus non-chemical). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686337/

Dal Sacco and colleagues (2005) described a patient who developed multiple tender nodules in the nasolabial fold 4 months after injection of Restylane. Biopsy revealed the presence of sarcoid-like granulomas. Interestingly, the patient also developed similar-appearing dermal lesions at previous sites of venipuncture and scarring. On further diagnostic workup, the patient was diagnosed with sarcoidosis. Based on the extent of her clinical disease and the presentation of dermal lesions in multiple sites of previous skin trauma, it was concluded that the hyaluronic acid injections triggered a sarcoidal skin reaction in a background of a pre-existing but subclinical case of sarcoidosis (“scar sarcoidosis”). This is an AUTOIMMUNE DISEASE.

I wrote already about my issue, but it does not appear to have posted. I had both botox and juv put in in Nov of 2012. i decided to get more juv put in on one side and in my lip area mid dec 2012. About 2 days later I awoke a low humming in my ears as well as dizziness, fullness in my right ear, sinus presure beyond belief, jaw pain, head pressure and many many more issues. It is now 4 months later and i still have all these issues. I cant help but wonder if it is related to this. My question to you all is, do you think I should get it dissolved with that stuff (cant remember the name) to see if my issues go away. I wonder if it has sort of clogged up my sinus area a bit and caused issues. she did that one side really close to the maxillary area. I go in to talk to the doctor tuesday to discuss. I know he will say it is not related. I have been to countless doctors for answers. I have done cts scans, mris, blances tests. so much stuff. no answers. It could be totally unrelated but i cant help but wonder.

I just learned in addition to flu symptoms i have enlarged lymph nodes in my lung and most symptoms of sarcoidosis. I am now on a prescription for prednisone which is what sarcoidosis is treated with. I will know in a couple days if i feel better.

I spoke to a pharmacist at Midicis Aesthetics about Restylane and Restylane-L.The only diff is the L contains Lidocaine. The ingredients are: Hyaluronic acid is generated by Strep bacteria (Restylane contains gram positive bacterial proteins) NOTE: "Hyaluronan (also called hyaluronic acid or hyaluronate or HA) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi, and can be very large, with its molecular weight often reaching the millions.[2] One of the chief components of the extracellular matrix, hyaluronan contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors. The average 70 kg (154 lbs) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (degraded and synthesized) every day.[3] Hyaluronic acid is also a component of the group A streptococcal extracellular capsule,[4] and is believed to play a role in virulence.[5][6]" Wiki *The Restylane L contains saline and lidocaine. Both products have the same adverse reactions, or as Medicis calls the reaction, allergic or hypersensitivity reactions, which are nausea and vomiting and headaches, and anaphylaxis (the only reactions that they state as know and expected). So basically what we are likely reacting to is either the Lidocaine or the Strep bacteria proteins, bcuz Hyaluronic acid is found in the body. The definition of a hypersensitivy reaction, which it is specified as the nausea, headaches, vomiting, according to Medicis/Restylane is: Reaction produced by the immune system, which includes allergies AND autoimmunity. It requires a pre-sensitized (immune) state of the host - So I am guessing this means since I had nausea right away with the injection, I was exposed in the past to one of the ingredients and was allergic to it before the injection, (Bacteria or lidocaine), OR that is what they want us to think...What if it causes an autoimmune disease, like gluten causes celiac disease? Consider getting allergy & antibody testing done for the gram positive strep bacteria and maybe lidocaine. FURTHER RESEARCH: The Hyauluronic Acid is chemically modified with unknown added ingredient-CHEMICAL SENSITIVIES? "Native hyaluronan has a relatively short half-life (shown in rabbits) so various manufacturing techniques have been deployed to extend the length of the chain and stabilise the molecule for its use in medical applications. The introduction of protein based cross-links, the introduction of free-radical scavenging molecules such as sorbitol [found in fruits], and minimal stabilisation of the HA chains through chemical agents [!!!] e.g. NASHA stabilisation are all techniques that have been used. Research Due to its high biocompatibility and its common presence in the extracellular matrix of tissues, hyaluronan is gaining popularity as a biomaterial scaffold in tissue engineering research. In particular, a number of research groups have found hyaluronan's properties for tissue engineering and regenerative medicine are significantly improved with crosslinking, producing a hydrogel. This added feature allows a researcher to form a desired shape, as well as to deliver therapeutic molecules, into a host. Hyaluronan can be crosslinked by attaching thiols (trade names: Extracel, HyStem), methacrylates, [PLASTICS] and tyramines (trade name: Corgel) [Tyramine intake has also been associated with MIGRAINE] Hyaluronan can also be crosslinked directly with formaldehyde [POISON] (trade name: Hylan-A) or with divinylsulfone (trade name: Hylan-B) [SYNTHETIC RUBBER]" Wiki