I read prior to using it that it caused depression, but I thought "oh I am a happy person, I don't have to worry about that.. plus, nothing is worse that acne!" I went on it and it did clear my skin up... however, it made me super depressed. I didn't want to go out, looked in the mirror and still saw my old skin, cried constantly. It was just not good. And after 2 years of being clear, my acne came back anyway. I would not suggest Accutane to anyone. When my acne came back I did monthly microderms and chemical peels while on Menocycline for a couple months. That has cleared me up since : ) Prior to all that, I had tried everything and nothing ever worked. Microderms are the way to go. Much more natural approach than Accutane.