Permanent Paralysis w/ Long-Term Botox Use?

Long term use of Botox injections will not permanently weaken or paralyze the muscles. The muscle activity will resume and with time, the effect will be as it was prior to the first treatment with Botox.

Botox results tend to last longer and longer with repeated use.  If you cease Botox therapy, the normal musculature will return in time.  Some think that the brain may stop sending the message for those muscles to move, since these messages were ignored for so long.  I have heard some patients say that, so it may be true.  But it's really hard to do a study on that because of the long-term nature of the hypothesis.

Botox results are temporary but with repeated, regular use you may get out of the habit of making certain facial expressions, such as a frown/scowl.  If the Botox does train you not to make that expression it might appear to last longer or you may not need as high a dose in the future, but it usually takes at least 1-2 years of continued use (without letting it wear off completely between treatments) and doesn't occur in everyone.