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What Are Artefill Injection Risks?

I heard a doctor on TV say that Artefill was risky, but my friend had it injected and it looks really good. Is Artefill safe? Does anything last as long, like maybe silicone?

Doctor Answers (12)

Artifill has inherent disadvantages

+8

Artifill uses PMMA (plastic) beads, materials which are non-biologic and have no natural defenses against infection. If bacteria form around the beads, the body has no defense against them (i.e. no blood vessels of its own to carry white blood cells or antibiotics) as the bacteria multiply on the foreign object. The body will often try to encapsulate the involved area with scar tissue, calcium deposits and inflammatory tissue as white blood cells degranulate, or discharge their acid sack contents in an attempt to kill the bacteria. This creates an inflammatory lump that is often palpable below the skin surface. Occasionally the lump becomes infected and red. This process can take months to years to occur. The beads and inflammatory reaction can move over time as the dynamic process of the inflammatory response of the body acts on the bead complex.

We have found in our practice the best way to treat the problem is to surgically remove the lumps, usually with small incisions hidden if possible in natural creases or anatomic borders.

Autologous tissue from the patient's own tissues such as LiveFill (fascial fat grafts), all alive when they are placed, are a more permanent, more durable method of augmenting soft tissue in the face. LiveFill grafts have the disadvantage of not being universally available and of being more expensive than injected fillers, and requiring an outpatient surgical procedure to place.

If patients are interested in temporary fillers, current hyaluronic acid (HA) fillers last approximately 6 months (Juvederm, Restylane), and are therefore less durable than Artefill. However HA fillers offer much greater biocompatability, and tend to go away over time. If the results are undesireable, they eventually go away. This is not the case with Artecoll, Artefill or silicone, where bad effects of the injection are often permanent.

There are many patients who have had Artecoll and Artefill injections with no problems and have appreciated the long lasting results. However I have difficulty balancing the risks or a permanent or semipermanent filler with the benefits of longer duration of action. I would agree with the statement that they are risky, for the reasons above.

Beverly Hills Plastic Surgeon
5.0 out of 5 stars 82 reviews

Long term development of granulomas

+5

I have seen draining granulomas develop in patients 8 years after their ArteFill was injected who had no problems in between. This is very alarming and difficult to treat. Avoid all permament fillers!

Seattle Plastic Surgeon
5.0 out of 5 stars 44 reviews

Artefill and mass hysteria? Let's separate the truth from the nonsense.

+4

First, let me express my skepticism about how many "draining granulomas" my colleagues have seen from ArteFill "8 years after" its injection. Artefill was approved for use in 2006 (THREE years ago). So any patients injected eight years ago would have either 1) not been injected with Artefill, or 2) were from the very early beginning of the experimental study group of patients prior to its approval.

Indeed, granulomas are hard to treat (not impossible). But what is the relative risk? My same colleagues who ply the public with hysterical claims of its risk are the same ones who confidently recommend surgical procedures with much higher rates of complications. The granuloma risk from Artefill is on the order of 1 in 800 patients. The risk of having a bad outcome from rhinoplasty? Perhaps as high as 1 in 10 to 1 in 20 patients.

I like Artefill, I use it (in addition to other fillers), and I've injected family members with it. It needs to be done correctly and for the right indications. But let's put risk into perspective.

All the best,

--DCP

Jacksonville Facial Plastic Surgeon
5.0 out of 5 stars 12 reviews

Artefill, formerly known as Artecoll

+3

ArteFill is a gel filler consisting of millions of synthetic microspheres (polymethylmethacrylate or PMMA) suspended in purified bovine (cow) collagen. This product sounded like a bad idea to me when it was first introduced. Countless reports of lumps, bumps, and granulomas by patients who have been injected with this product. Over the last few years, this product has become less and less popular and currently, the company is in bankruptcy.

Web reference: http://www.michaellawmd.com

Raleigh-Durham Plastic Surgeon
4.5 out of 5 stars 31 reviews

Removing artefill and bioalcamid and silicone - Los Angeles

+2

I do not advise patients to undergo augmentation with permanent fillers. Complications are difficult (but sometimes possible) to treat.

Raffy Karamanoukian Los Angeles

Web reference: http://karemd.com/cosmetic-dermatology/34/lip-silicone-removal.aspx

Los Angeles Plastic Surgeon
5.0 out of 5 stars 43 reviews

Artefill can be good - but they are bankrupt

+2

Artefill is a good product but there are some long term problems such as granulomas which can be very difficult to treat. Of note, the company which makes Artefill filed for Chapter 7 bankruptcy at the end of 2008.

There are other permanent options including silicone, but some fat from the belly or thighs can be used in places that would be otherwise amenable to Artefill or other permanent fillers.

Dallas Facial Plastic Surgeon
4.0 out of 5 stars 10 reviews

It's what is keeping my face looking young!

+1
I work pretty much all the time, and I'm no spring chicken, so I need to use something that actually LASTS, that I can BUILD UPON as time marches on.  It is absolutely safe as long as you're not allergic to the bovine collagen carrier, so we ALWAYS do a skin test before using this on any patient.  The beads are microscopic, and the body puts a ball of collagen around each one, so the result is smooth, natural and permanent - it's YOUR tissue!  Just be certain you go to an absolute expert injector who has injected thousands of syringes as we have.
Boca Raton Dermatologic Surgeon
4.5 out of 5 stars 14 reviews

Artefill®'s safety lies in the hands of the injector

+1

I have been injecting Artefill® for many years now in practically every part of the face and body, including the hands, lower eyelids, acne scars, nose, vermillion border. I have only seen two small granulomas in well over 800 patients which were easily and rapidly treated.

As with all permanent fillers, only small amounts should be injected at a time and in multiple planes. An expert injector of any filler (whether it be temporary such as hyaluronic acid [Restylane®, Juvederm®, Belotero®], Radiesse™ or permanent such as Artefill®, Aquamid™ or fat) should have a light touch and avoid injecting "lakes" of filler which are far more problematic. Since the center of these "lakes" have no blood supply to receive antibiotics or the body's own antibodies, they can become more easily infected. The same holds true with any permanent filler, whether it be Aquamid® or natural fat transfer for that matter.

My patients and I have been extremely satisfied with Artefill®, and have seen less untoward effects than with many of the hyaluronic acid fillers (which produce a swollen, bluish tinge around the eyes on a number of occasions).

 

Los Angeles Plastic Surgeon
4.5 out of 5 stars 26 reviews

Artefill safety

+1

I have been using artefill or artecoll its previous product name for over a decade in Canada.  Its biggest risk is palpable lumps.  These are generally small and often palpable but not visible.  True granulomas are rare and I have never seen one  in the hundreds of cases ive done.  Artefill is most useful for correctiing pitted acne scars where small quantities are injected.  Its other use is in correcting subtle nasal bone asymmetry after rhinoplasty. In my opinion it should not be used in large quantities. It should be injected in sub dermal or deep dermal plain. When used for lip augmentation patients should be advised that they will likely  have palpable textural changes and possible lumps in their lips.

Web reference: http://www.solomonfacialplastic.com/botox-facial-fillers-lasers/artecoll-procedure.php?a=3

Toronto Facial Plastic Surgeon
4.0 out of 5 stars 17 reviews

Artefill is safe and FDA approved

+1

 Artefill is different from temporary injectable wrinkle fillers. The unique microspheres in Artefill are not absorbed by the body and provide the support your skin needs for natural, long lasting results.

You must be skin tested prior to treatment with Artefill. The carrier of the unique microspheres in Artefill is collagen. If no reaction to the skin test after four weeks, you may be treated with Artefill that day. Most people require more than one treatment to reach the level of correction that they want.

Artefill is technique sensitive as it must be injected mid to deep dermis. You will want to choose a Doctor who has experience injecting Artefill due to the importance of placement of the filler. 

I would advise against silicone injections as silicone tends to migrate and I have treated patients 10-15 years post silicone injections of face and other areas who present with delayed hypersensitivity reactions, granulomas and persistent edema.

 

 

Web reference: http://www.aristocratps.com/medspa/artefill/

New York Plastic Surgeon
5.0 out of 5 stars 38 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.