What is Cosmoplast?

CosmoPlast (and CosmoDerm) are collagen based fillers that do not require a skin test prior to treatment. Although they are less expensive than Restylane or Juvederm, the results last about half as long, or less. Use of CosmoPlast and CosmoDerm has dwindled since the introduction of hyaluronic acid based fillers several years ago (see below).
A new collagen based filler called Evolence also does not require a skin test and reportedly lasts longer than CosmoPlast due to a cross-matrix technology that holds the material together longer. Bruising and swelling are supposed to be minimized with Evolence compared to other fillers.
Restylane, Perlane and Juvederm are hyaluronic acid based fillers that also do not require a skin test and last 6 to 18 months depending on where it's injected, and how much is injected. The biggest benefit to hyaluronic acid fillers is that the effects can be reversed by injecting an enzyme to dissolve it if the results are undesireable.

To paraphrase GENESIS -
First, there was COLLAGEN. (Closed herd, cow derived Collagen) and Plastic surgeons / Dermatologist liked it "and it was good". But it lasted only 3-4 months and required 1-2 skin tests separated by 3-4 weeks before administration (to avoid giving it to people with allergies) and that was definitely NOT good.
Then, came human cadaveric Collagen CosmoDerm™ and CosmoPlast™ human collagen mixed with Lidocaine, a numbing medication. They required no skin tests and could be given immediately without waiting to check a skin tests. They were BETTER but not popular because it came from dead donors (and few people liked the idea of some of ol' Joe in their lips and wrinkles).
Then came Radiance / Radiesse a mixture of sea coral powder - calcium hydroxylapatite (CaHA) microspheres (diameter of 25µm to 45µm) suspended in a sodium carboxymethylcellulose gel carrier. It lasts nearly a year and acts by causing scar tissue to replace the gel carrier. It was better but cannot be used anywhere where a hard scar may be objectionable (lips, lower lids etc).
Then came Hyaluronic acid fillers - Restylane/Perlane and Juvederm. They lasted as long. Had no allergic reactions. Acted by holding on to water not by causing scar tissue. Caused NO allergic reactions and they ARE THE BEST.
The End.
Peter A Aldea, MD

Cosmoplast is a collagen based filler. It is derived from human collagen, actually from baby foreskins.
Being human derived it does not require allergy testing like its predecessor zyplast.
Cosmoplast is more cross linked than its stablemate Cosmoderm. It is meant to last a bit longer and is injected a little deeper.
There is still a role for these fillers. In fact, in talking with fellow injectors, these two are probably under utilized compared to the more glamorous hyaluronic acid fillers. They are very good at correcting superficial scars, crow's feet, and giving the lip definition.