Skin irritation using minoxidil ??

Minoxidil liquid generally has a higher alcohol concentration than the foam.  It is more drying and irritating to the scalp in some patients.  I would recommend switching to the foam version and if that continues to cause irritation, then try the application once per day.For my patients I have a lab formulate my own formulation of 5% minoxidil which has a proprietary blend of oils which helps with the irritation and scalp dryness.

Hello, 
Minoxidil is effective in protecting the non-transplanted hairs by keeping them in anagen phase for longer.  Patients often times need a blueprint for maintaining native hairs so that future procedures are not necessary.  Transplanted hairs have been reported to grow faster with minoxidil. Evidence has been reported by several studies with limited numbers including at a Consensus Report at the 9th Annual Meeting in 2002.  The main downside of minoxidil is irritation which is often mitigated by the use of foam.
Best,
Dr. Anil Shah

This is most likely due to the propylene glycol that is used to mix in your minoxidil.  Switch to the foam version.