Can Upneeq be used if you have implanted permanent lenses?

To answer your question: can I use Upneeq with a history of implanted lenses (uncomplicated cataract surgery)? Short answer: Yes, for most standard surgeries this will not cause issues and should be used only after a full recovery from your surgery and after an evaluation by your Ophthalmologist or Oculoplastic eyelid specialist.
Long answer: Upneeq (oxymetazoline) is in a class of medications that activate certain receptors in the body (alpha-receptors). This causes certain functions to occur based on where it is used and what has similar receptors around it. In the eyes, under specific formulation, it works on the upper eyelid's Muller muscle to contract the lid about 2 millimeters to temporarily reduce droopy upper lid (ptosis). It also happens to activate other receptors of the same type in the eye, most notably the dilator muscle of the iris (colored part of the eye). This may cause your eye to dilate slightly when using the drop. This action of dilation is also at the heart of most eye-related safety concerns. Some people can't get their eyes dilated when they go to the eye doctor because the bunching up of the colored iris when it folds up (like an accordion away from the center) can block an important eye-pressure relief drain. For this reason, before starting this medication I recommend evaluation with your eye doctor or an Oculoplastic surgeon like myself. since we are trained initially in eye evaluation and surgery then additional years of training specifically in facial plastic surgery around the eyes.