How to use Tretinoin Cream in Dark underarms? (Photo)

Tretinoin cream (generic; brand names include Retin-A, Renova, others) is a topical retinoid that can be used for certain skin conditions, but its use for dark underarms (axillary hyperpigmentation) is not a standard or widely studied indication. However, tretinoin has been studied for axillary lesions in the context of acanthosis nigricans, where it demonstrated efficacy and safety when used at 0.05% concentration[1].

How to use tretinoin cream for dark underarms:

Application: Apply a thin layer of tretinoin 0.05% cream to clean, dry underarm skin.
Frequency: Start with application every other night (2–3 times per week) to minimize irritation. If tolerated, frequency can be increased to nightly.
Duration: Use for at least 8–12 weeks to assess efficacy. Discontinue if significant irritation occurs.
Precautions: Avoid applying to broken or irritated skin. Use sunscreen on exposed areas if the underarms are exposed to sunlight, though this is less common.
Safety and efficacy:

Tretinoin 0.05% has been shown to be effective and safe for axillary lesions in clinical trials, with minimal side effects[1].
It is not specifically approved for axillary hyperpigmentation, but off-label use is possible if other causes of dark underarms (such as acanthosis nigricans) are present.
Monitor for irritation, redness, or peeling, and adjust frequency as needed.
Tretinoin 0.05% cream can be used on dark underarms, starting 2–3 times per week and increasing as tolerated, with monitoring for irritation. It is safe for axillary use in clinical studies, but is not specifically approved for hyperpigmentation

Hello! My name is Jessica, I am a physician assistant, and one of the providers at Aesthetic Skin in Winnetka and Chicago. This is a great question. Using tretinoin cream can be an effective approach for addressing pigmentation issues, including dark armpits. To use it safely and effectively, start with a gradual approach. If you’re new to tretinoin, it’s advisable to begin with applying it once or twice a week. This allows your skin to acclimate to the active ingredient. As your skin adjusts, you can increase the frequency to every other night and eventually aim for nightly use, depending on your skin's tolerance. When applying tretinoin, it’s important to follow a proper routine. First, cleanse your armpits with a gentle cleanser and pat them dry. Afterward, use a pea-sized amount of tretinoin cream, applying it evenly to the affected area. Avoid using it on broken or irritated skin, as this can lead to further irritation. After allowing the tretinoin to absorb for about 20-30 minutes, consider following up with a gentle, hydrating moisturizer to help minimize potential dryness or irritation. As for using tretinoin on dark armpits, it can be safe, but caution is advised. The skin in the armpit area is sensitive, so it's wise to perform a patch test on a small section first to check for any adverse reactions. Keep in mind that improvement in pigmentation may take several weeks to months, so consistency is key. Be patient with your regimen, and prioritize skin health by protecting the area from sun exposure, as tretinoin can increase sensitivity to the sun. By following these guidelines, you can effectively incorporate tretinoin into your skincare routine while addressing your concerns about dark armpits. I hope this helps and best of luck!