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If there is a true allergic reaction, not a side effect, it is extremely rare, almost unheard of by most physicians who have done Botox treatments for many years. There is a chance that someone could be allergic to an ingredient in the liquid saline that is used to mix the Botox powder. IF someone thinks they have had a reaction to Botox, they should let their doctor know who could let the company, Allergan know. Furthermore, do not have the Botox again, unless you are tested by an allergist to the Botox and mixing liquid the doctor has used.
Toxic reactions are also extremely uncommon with the doses of BOTOX used for cosmetic purposes. The vast majority of individuals do great with this treatment which is why it is so popular.
In most cases where an allergic reaction occurs with Botox, it is to the carrier that comes along with the drug. People allergic to vaccinations, albumin or eggs have been known to have reactions to the medicine, but this is rare. A true allergy to the botulinum toxin would be very uncommon. The body may form antibodies against the toxin, which will block its effectiveness, but doesn't usually cause any noticeable immune reaction.
Although there is always a theoretical risk, I have never heard of an actual report of an allergic reaction to Botox. The product Botox contains ingredients other than the actual neurotoxin. Human albumin is more likely to cause a reaction, and again, I've never heard of it being a problem with Botox injections The risk appears to be low.
It is very rare to have an allergy to Botox. Although, I suppose it could happen. I have yet to see one in my practice.