Does Xeomin work just as well as Botox for jaw line reduction (masseter muscle)?

I'm considering getting 15 units of Xeomin on each side of my masseters to slim down my jawline to a nice v shape. I see that Botox is more popular and my medspa doctor prefers to use Xeomin. Does Xeomin do just as good of job as Botox?

Doctor Answers 9

Xeomin for Jawline Reduction

Yes, Xeomin can also be used to effectively treat the masseter muscle and slim the jawline. Like Botox, Xeomin is a neuromodulator that works by weakening the masseter muscle and causing it to reduce in size. For patients who want to slim their jawline without surgery, Xeomin might be an ideal treatment.

Baltimore Dermatologic Surgeon
3.7 out of 5 stars 7 reviews

Difference between Botox® and Xeomin®

The FDA has deemed Xeomin® to be equivalent to Botox Cosmetic® after evaluating the studies for both when each sought FDA approval. Botox Cosmetic® injections have been much more thoroughly-studied (in every facial area) and are more "popular" on the internet in large part because Botox Cosmetic® has been FDA-approved and on the market in the USA for many years longer than Xeomin®.

Manjula Jegasothy, MD
Miami Dermatologist
5.0 out of 5 stars 9 reviews

Xeomin works similarly

Hi! Xeomin is very similar to Botox. I have used both, with the same dosing, and my patients find the results excellent for either product. 

For masseter hypertrophy, I usually give 20-25 units per side and have you return in 2-3 weeks, at which time we compare your before photo and see if we need more treatment. Every person is different! This is a wonderful procedure. 

Andrea Hui, MD
San Francisco Dermatologic Surgeon
5.0 out of 5 stars 35 reviews


Xeomin is as effective as botox for the Masseter muscle. I use them interchangeably. Thank you for your question.

Kristin J. Tarbet MD, FACS
Bellevue Oculoplastic Surgeon
5.0 out of 5 stars 24 reviews

#Botox #Xeomin - Does Xeomin work just as well as Botox?

Yes, it does.  Any of the neuromodulators (Botox, Xeomin and Dysport) work more or less interchangeably.  They affect the muscles in the same manner.

However, the dosages are different.  In general, 1 unit of Botox works the same as 1 unit of Xeomin but you need about 2.5-3 units of Dysport to achieve the same effect.

As the masseter is a large muscle, you will need relatively more neuromodulator than you would for the smaller muscles of the face.  It is obviously appropriate to start slowly and add more once you've seen the effect of a smaller dose.

You should of course go over all of this with your own plastic surgeon.

I hope that this helps and good luck,

Dr. Alan Engler
Member of #RealSelf100

Alan M. Engler, MD, FACS
New York Plastic Surgeon
5.0 out of 5 stars 125 reviews

Xeomin for Jaw Line

Yes, both work the same neuromodulators. Xeomin will often work faster than Botox. However, Botox has been in the market for much longer and has been studied more extensively. It is a personal preference. The most important factor in achieving a good result is actually the injector. Treatment by a Expert injector is highly advised. Patients can possibly need multiple treatments. Hope this helps.

Shelena Lalji, MD
Sugar Land OB/GYN
5.0 out of 5 stars 4 reviews

Xeomin for Masseter Muscle

Yes, Xeomin is an effective treatment for the reduction of the jaw line and masseter muscle. Xeomin and Botox work in the same way to calm an overactive masseter muscle and slim the jawline. It is best to seek treatment from a Xeomin expert who has years of training and experience using Xeomin to treat the jawline and masseter muscle.

Karen Beasley, MD
Baltimore Dermatologic Surgeon
5.0 out of 5 stars 3 reviews

Does Xeomin work just as well as Botox for jaw line reduction (masseter muscle)?

Yes, Xeomin should work just as well as Botox for anything. They both have the same active ingredient, so they are dosed the same and should have very similar effects. There are some molecular differences in the formulations that may lead to small clinical differences.

Eric Desman, MD
Alexandria Plastic Surgeon
4.9 out of 5 stars 9 reviews

Does Xeomin work just as well as Botox for jaw line reduction (masseter muscle)?

Xeomin should work similarly to Botox in the masseter muscle. There is a 1:1 conversion of Botox to Xeomin units. Depending upon the amount of slimming you desire 30U total might not be enough. In many cases, up to 50U is required for the first treatment for jawline slimming. I hope this information is helpful for you.

Stephen Weber MD, FACS
Denver Facial Plastic Surgeon

Stephen Weber, MD, FACS
Denver Facial Plastic Surgeon
4.9 out of 5 stars 129 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.