I would consider it safe to treat with Ellanse in an area which had botox 3 months ago How does it work Polycaprolactone (PCL) is a medical polyester which has been used for medical purposes for over 50 years- found in sutures, orthopaedic implants and wound dressings. In the body, PCL is gradually broken down by hydrolysis into carbon dioxide and water by the body. The PCL microspheres used in Ellanse are designed to offer optimal biocompatibility. They have a smooth surface, a spherical shape and a size of approximately 25–50 μm Carboxymethylcellulose (CMC) is a natural material derived from cellulose that is often used as a gel carrier for injectable collagen biostimulators (Ellanse, Sculptra, Radiesse). It functions to act as a medium for collagen biostimulator particles, and to provide short term volume replacement for 2-3 months. Working together, the CMC gel delivers immediate results, while the PCL microspheres act as a biostimulator, to ramp up production of your own collagen over the next 2-3 months. This improves skin elasticity and creates a more youthful appearance.