While this probably has not been officially studied, it is reasonable to expect that the tissue growth stimulation effects of Sculptra are less if you constrict the blood vessels of the face with the drug that is in tobacco, nicotine. It doesn't mean you won't get an effect though. If you really want to improve your appearance in the long term, consider a smoking cessation program. Many good methods are available to help you through the process. Remember that tobacco ruins the blood supply to the skin and causes early wrinkles and problems with skin texture resulting in premature aging. Maintaining your looks is a great excuse to stop smoking. Contact your primary care doctor of you want assistance.
Sculptra stimulates the production of new collagen in the skin. Smoking breaks down collagen so you will not have the full benefit of your Sculptra treatment. Another consideration - depending on where your Sculptra is placed, you may develop uneven collagen production around your smoker's lines.