Are patients with POTS candidates for Sculptra?

Question

Can I get Sculptra if I have POTS? I know they say don’t get Sculptra if you have an autoimmune disorder. I have got a few different answers. Thanks.

Anna Chacon, MD, FAAD · Answer

Thank you for your question, it’s a great one. While Postural Orthostatic Tachycardia Syndrome (POTS) is not classified as an autoimmune disorder in itself, it is sometimes associated with autoimmune conditions or dysautonomia, which raises understandable concerns when considering treatments like Sculptra.

Sculptra (poly-L-lactic acid) is a biostimulatory filler that works by stimulating your body's own collagen production. Although not an absolute contraindication, Sculptra does carry a precaution for use in patients with autoimmune conditions, since stimulating the immune system could, in theory, exacerbate certain underlying issues.

If you have POTS without any confirmed autoimmune component, you may still be a candidate for Sculptra, but the decision should be made on a case-by-case basis. It’s essential to:

Review your full medical history with your healthcare provider

Ensure your condition is well managed

Monitor closely post-injection for any adverse reactions

As always, consult with a provider experienced in treating patients with complex medical conditions before proceeding.

Let me know if you’d like help setting up a consultation or if you have more questions!

Michael A. Persky, MD · Answer

Hello there Funny,
Postural orthostatic tachycardia syndrome (POTS) has recently been associated with an autoimmune antibody.  We have treated patients with autoimmune conditions with Sculptra, it depends on the severity of the condition.  I have had one patient with Lupus have a reaction and no longer treat Lupus patients with Sculptra.  If you choose to be treated, I would recommend treating your temples below muscle to see how you respond.  Sculptra may have increased incidence of nodules and may flare up autoimmune conditions in those patients sensitive to it.  Good luck and be well.
Michael Persky, MD
Encino, CA

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