Does consuming caffeine in coffee reduce the effects of hyaluronidase to dissolve Voluma, if consumed before or after treatment?

Caffeines in combination with sugar (lattes, frappes, etc.) can raise blood pressure, which heightens the body's metabolism. Receiving injectables with a heightened metabolism can theoretically cause reduced effect of injectable product.  However, it is important to note that this differs by patient. Patients with naturally high metabolisms often experience less duration of filler products and botox injections. I would presume this to be similar with effects of hyaluronidase.I hope this information helps you. Best, Dr. Anil Shah

Thank you for your questions. There have been some bench-top research papers showing inhibition of collagen synthesis secondary to caffeine. However, this is a theoretical topic and has not been studied in actual patients in a blinded/controlled clinical trial to my knowledge. That is to say that I think that oral intake of caffeine from coffee is not going to cause any significant effects with HA fillers and/or hyaluronidase. You have to be careful about extending the findings of specific studies to real-world scenarios. Hope this helps!Dallas R. Buchanan, MD, FACSOwner & Board-Certified Plastic SurgeonVIVIFY plastic surgery