Does consuming caffeine in coffee reduce the effects of hyaluronidase to dissolve Voluma, if consumed before or after treatment?

Question

I read caffeine in a person's system may render tissues partially resistant to the action of hyaluronidase; and it may cause patients to require a higher dose. Does that apply also when used to dissolve Voluma? (I know hyaluronidase is used for more than just dissolving filler). Should a patient wanting a full hyaluronidase treatment result avoid caffeine day of treatment in hours before and after? Thanks.

Anil R. Shah, MD · Answer

Caffeines in combination with sugar (lattes, frappes, etc.) can raise blood pressure, which heightens the body's metabolism. Receiving injectables with a heightened metabolism can theoretically cause reduced effect of injectable product.  However, it is important to note that this differs by patient. Patients with naturally high metabolisms often experience less duration of filler products and botox injections. I would presume this to be similar with effects of hyaluronidase.I hope this information helps you. Best, Dr. Anil Shah

Dallas Buchanan, MD · Answer

Thank you for your questions. There have been some bench-top research papers showing inhibition of collagen synthesis secondary to caffeine. However, this is a theoretical topic and has not been studied in actual patients in a blinded/controlled clinical trial to my knowledge. That is to say that I think that oral intake of caffeine from coffee is not going to cause any significant effects with HA fillers and/or hyaluronidase. You have to be careful about extending the findings of specific studies to real-world scenarios. Hope this helps!Dallas R. Buchanan, MD, FACSOwner & Board-Certified Plastic SurgeonVIVIFY plastic surgery

Does consuming caffeine in coffee reduce the effects of hyaluronidase to dissolve Voluma, if consumed before or after treatment?

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