How long until spironolactone starts working again for acne?

Question

I was on spironolactone for 4.5 years. About 5 months ago, I decided I would start weaning myself off due to my skin being consistently clear and being almost 26. For a couple of months I took my usual 100mg every other day, then every couple days. Then about 3 months ago I stopped completely. The last couple of weeks I started breaking out again and restarted on spironolactone. I have now been on it again for 3 weeks. I was only off for 2 months, how long will it take to start clearing?

Marla M. Klein, MD · Answer

Spironolactone is a wonderful treatment option for hormonal acne.  Some people see improvement as soon as two weeks, while others can take two or three months to clear up.  Don't give up.  If that dose worked before it is likely to work again.  Just keep taking it faithfully and I believe your skin will be clear again very soon.  Kindly yours, Marla Klein MD

Estee Williams, MD · Answer

Be patient! Spironolactone can take 6 weeks to give a noticeable improvement in acne. Stick to it. Be well.

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