How Safe is It to Use Restylane Between the Eyebrows?

The glabella or central brow area has relatively superficial vessels which can be occluded (and cause skin necrosis) by injection with any filler. Therefore, great care is exercised whenever this area is treated with fillers.  Generally speaking, the first line of therapy for such glabellar lines is Botox or Dysport, which minimize muscle activity and the ensuing vertical lines.  Fillers can be applied only if Botox results are insufficient

Hyaluronic acid fillers such as Restylane and Juvederm are safe for use in many areas of the face, including between the eyebrows.  Combining this with Botox or Dysport for relaxation of the muscles is a great way to treat deeper lines in the glabella (the area between the nose and forehead).