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For dry skin or to tolerate Retin-A better you can definitely mix a moisturizer. The efficacy is the same and you will have less peeling. Hope this helps Dr. Grant Stevens Marina Plastic Surgery Associates Marina del Rey, CA The Institute
Because Retin-A products can be drying, it is best to combine them with a good, thick moisturizer. You can mix them together and apply, or better, in my opinion, is to apply the Retin-A, leave for a few minutes, then apply the moisturizer over it. Make sure you apply Retin-A to clean, dry skin.
Retin-A is a good option for skin rejuvenation. Sometimes, Retin-A can be drying to the skin. For patients that find this to be a problem we often will recommend mixing the Retin-A with moisturizer. In doing so, the concentration of the medication is lowered but this does not seem to be a problem.