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Both Renin-A and Renova have the same active ingredient, tretinoin. Renova has some moisturizers in it and tends to have a more elegant feel. Renova also tends to be more expensive. Renova is a 0.02% tretinoin formulation while Retin-A comes in 0.025, 0.05, and 0.1%. As far as the rejuvenation attained with the different strenghts, the low dose and high dose are probably comparable. However, the side effect of dryness can be more of an issue for people at the higher strenghts.