Can Restylane or Juvederm Cause Edema when It Starts to Break Down?

These filler work by holding water.  We are not accustom to assessing negative volume which is what is seen as helpful volume created by filler begins to disappear.  For quite a while with these fillers, what can be left is not our original face, but what you are describing as doughy ridges.  The solution is to have these adjusted with hyauronidase enzyme.  Generally, this is very effective for modify these ridges when they occur.  The challenge is not getting rid of them in my experience.  Rather, the challenge is how to modify them without removing any of the desirable volume effect.  By preserving helpful volume, it is possible to extend the benefits of the treatment many more months.  Naturally just as placing the original filler is an art form, so is adjusting these residual volumes.  Occasionally, very little filler is holding a fair amount of water.  The enzyme touches this, releases the water, and, well, it is hard not to feel the bottom has been let out of a good thing.  I always warn patients of this risk, and the solution is more filler, which they are generally very happy to pay for.  

To answer you other question, no I do not believe that this is rare.  However, it is very easy to manage.  The key to monitor your service, and return to your injector for any adjustments should they become necessary and not simply ignore an issue because these fillers do persist for a long time.  Have the adjustment and get as much benefit from a service as possible.

I have had one patient who remembered having some filler injected into her lower eyelids about three years prior to coming to see me after she was referred by a physician to work up her swelling. I had noticed a sheen and consistency consistent with a hyaluronic acid rather than mere lower eyelid puffiness. After one injection of hyaluronidase her right lower eyelid which had the largest swelling resolved completely within a week and the other eyelid needed an additional treatment. 

Why there is persistent product retaining this swelling is hard to say, but if it were only water, not filler or hyaluronic acid, it would not have gone away after the hyaluronidase injection.  She did not have Botox injected around the Crow's feet.  Some people who have lower eyelid puffiness have worsening when the pump action of the muscle that helps drain the fluid, is inhibited by the Botox.  This, however, could not be the reason for the patient's problem as described above.

Dear Raleigh,

I have seen swelling after the injection of hyaluronic acid fillers (Restylane, Juvederm, etc) up to a year and a half after the injection.  This edema quickly resolves after the injection of Hyaluronidase.