Can Restylane in a Blood Vessel Cause an Embolism That Can Cause Death?

Dear Saint Clair Shores

BOTOX, Dysport, and other Botulinum toxin preparations are safe for the 11 lines area between the eyebrows. The treatment is extremely safe and proven effective.  It is possible to inject into a blood vessel in this area, and the tiny amount of agent that will get into the blood stream is not associated with systemic side effects.  Even the FDA which recently required so-called black box warnings which for Botulinum toxin agents, has said that Botulinum toxin used for cosmetic purposes including the 11 lines is safe and has not been associated with systemic complications.  The black box warnings were required because doctors have been using very high doses in sick infants with complex medical problems and this has been associated with systemic complications including death.  Important to understand that so much in medicine is a question of dose.  Two acetaminophen helps your headache but 200 acetaminophen damages your liver.

Different story for fillers.  The injection of fat into the glabellar area has caused embolic stroke and death.  Other fillers including hyaluronic acid fillers injected into this area have caused central retinal artery occlusion with visual loss and blindness.  More commonly, these injections can damage collateral circulation in the glabellar area causing skin necrosis in the glabella and as far away as the tip of the nose.  Consequently injection in this area must only be done in the epidermis or not at all.  

If you are planning BOTOX or Dysport injection for the 11 lines, this is very safe and does not affect the circulation-relax.  However, the best advise is to avoid having well meaning injectors place filler in this area the risk of this procedure is real.

There has not been a case of an embolus causing death that I am aware. Restylane and Juvederm would be safe (nothing is without risk) for the glabella region in the forehead between the eyebrows (the "11") but Perlane, Juvederm Ultra Plus and Fat Injections, which are thicker fillers,  increase the risk of interference of blood flow to the middle forehead which can cause ulceration, necrosis (death of the skin) causing scarring and shoud not be used in this region.

First let me point out that the usual first line approach to the vertical lines between the eyebrows is Botox rather than a filler because it is hyperactive muscles in that area that cause the wrinkles to form. If that doesn't completely correct it then a filler such as Restylane is considered. The complication you are describing where the filler can go into a blood vessel is very rare and the result could be an area of skin that dies, but it would not cause death of the patient! These rare cases would usually heal without permanent problems based on the reports that I have seen (I have never personally had a case of it.)