Hi there- I'm afraid too much is being made of this risk... Here are a few facts you may not be aware of... The risk of changes in eye color only exist if you allow the product to get INTO your eyes on a repeated basis. The product and its applicators make this truly difficult to do- you would almost have to be trying to do it. The risk ONLY applies to those with GREEN OR HAZEL EYES. Why? Because the problem occurs when the product acts on existing pigment cells in your eye. Those with Brown eyes need not worry- their eyes are ALREADY pigmented, and those with blue eyes have NO PIGMENT cells in the eye in which the product might cause a change. This problem has only actually been seen to occur in patients using Lumigan for glaucoma- in which they were DELIBERATELY placing the product into their eyes- and even in this population, the risk was extremely low. So, the bottom line is that if you have green or hazel eyes AND are unable to apply mascara without poking yourself in the eye because your hands shake or for some other reason, you are probably correct to avoid Latisse. Otherwise, I think your risks are VERY low.