Transport of poly-l-lactic microspheres in sculptra?

Hello! My name is Jessica, I am a physician assistant, and one of the providers at Aesthetic Skin in Winnetka and Chicago. This is a great question. The poly-L-lactic acid (PLLA) microspheres used in Sculptra are designed for gradual absorption and biocompatibility. When injected, the majority of the microspheres remain at the injection site, where they stimulate collagen production over time. While some small amounts may enter the bloodstream, studies suggest that this percentage is minimal, with most of the material staying localized. As for biodegradation, PLLA breaks down into lactic acid, a naturally occurring substance in the body. This lactic acid is then metabolized into water and carbon dioxide, which can be easily excreted. The process typically occurs over several months, allowing for a gradual and natural enhancement of facial volume without significant adverse effects on the body. I hope this helps and best of luck!