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Thanks for your question. It is an interesting idea. Tattoos fading while on accutane is not a commonly seen problem, but I suppose if the skin is excessively dry and peeling, it could cause some irritation in the skin where a tattoo is, and it might lose some ink. I am just speculating, however, and have not seen this phenomenon in real practice. I would definitely try and moisturize the skin over the tattoo as well as you can, and keep it covered in the sun. Best of luck!