Would Radiesse and Renuva help smooth out nadolabial folds? (photo)

Based on the photo you have provided, it does appear that you have some volume loss in the pyriform fossa area. Radiesse is a calcium hydroxylapatite filler that can be used to add volume to the area and help smooth out nasolabial folds. Renuva is a regenerative adipose matrix that contains extracellular matrix components derived from donated human adipose tissue. It can be used to help restore volume and improve the texture and quality of the skin.
Both Radiesse and Renuva can be effective options for treating volume loss in the pyriform fossa area. They can help add volume and provide a longer-lasting result than hyaluronic acid fillers. Additionally, they may not cause the same issues with persistent edema that you have experienced with hyaluronic acid fillers.
It's important to note that both Radiesse and Renuva are more invasive procedures than hyaluronic acid fillers, and there may be some downtime associated with the treatments. Additionally, as with any filler or cosmetic procedure, there is always a risk of side effects, such as swelling, bruising, and infection.
In summary, Radiesse and Renuva can be effective options for smoothing out nasolabial folds and restoring volume in the pyriform fossa area. It's important to consult with a licensed dermatologist who can evaluate your specific situation and recommend the best course of treatment for you. They can discuss the potential benefits and risks of each treatment and help you make an informed decision.

Radiesse and Renuva could both be great options to support the pyriform fossa and smooth out the nasolabial folds without relying on HA fillers.
Given your history of persistent swelling with HA fillers, you may also want to consider PRF EZ Gel. It’s derived from your own blood and creates a natural biostimulatory filler with minimal risk of migration or chronic edema. We've been seeing some excellent results here.

Radiesse Plus is an excellent product for facial support and tissue repositioning.
But logically 'nasolabial fold' is, in most cases, a result of tissue descent, therefore before placing either Radiesse or HA fillers, talk to your injector about creating an appropriate full lateral and medial cheek support. Unless there is a nasolabial 'crease', nasolabial fold should not be and in most case does not need to be 'filled'.