Can Botox Go Bad or Get Diluted?

Depending on how the Botox is stored and how long ago it was reconstituted (it comes as a freeze dried powder and must be mixed with saline before use) the activity of Botox can in fact decrease.  Dilutions do vary amongst providers, but the number of units is the determining factor in efficacy.  

Botox is reconstituted, not diluted. There are several factors that come into play with regard to efficacy of treatment and you should follow up with your provider with your concerns.

Botox does start losing its effect depending on the age of the batch of Botox and when it is reconstituted (when is the saline put into it). Sometimes its a function of not enough Botox being injected, or not being placed properly. Rarely, one can lose effectiveness and not respond to Botox with repeated usage. ~ Dr. Benjamin Barankin, Toronto Dermatology Centre.