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Posted underSpironolactone For Acne q&a

Spiro stopped working? Did I become immune?

sayyadinnaJan 14, 2017
I've been on Spironolactone & Minocycline (100mg daily) since 2012 and had clear skin since then. I went off for a while when I was without insurance. Now I'm back on both & they worked great for about a year but over the last few months it seems like they've stopped working. I'm taking em, but my cystic acne is back bad. My derm suggested that we up the Spyro to 200mg a day but I really fear an IB. Did I become immune? Will I experience an IB by upping the dosage? Will this even work? Thanks!

Answers (1)

From board-certified doctors and trusted medical professionals
Dr. Reuel Aspacio, MD, FAAD - Account Suspended
Board Certified Dermatologist
Answered on Feb 27, 2020
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Davin Lim, MBBS, FACD - Account Suspended

Unlike antibiotics, there are no interactions between the pill and spironolactone. All safe. If you are planning pregnancy, talk to your dermatologist about coming off the spiro and onto a pregnancy safe acne prevention regime. All the best, Dr Davin Lim 

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Sherry L.H. Maragh, MD

Patient EM0705, Yes, the rapid heart rate that you were experiencing could have been secondary to starting the Spironolactone orally, as this a diuretic that suppresses the hormone DHEA & can lower your blood pressure, in result increasing your resting heart rate at times.  In our office...

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Victoria Negrete, MD

Spironolactone is contraindicated in pregnancy as it is well known to cause birth defects. I advise all my patients to stop spironolactone at least one month before trying to get pregnant.

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