Is Microdermabrasion Safe While on Tetracyclines?

No worries.  Microdermabrasion is safe and in fact a useful adjunct to your other acne treatments.

In my practice many acne patients are taking tetracycline or similar antibiotics while being treated with microdermabrasion.

Microdermabrasion is safe while you are on tetracycline.

There is no problem with microdermabrasion while on tetracyclines. I would not do microdermabrasion if you are on any kind of topical or oral retinoid, such as: accutane/isotretinoin, tretinoin, tazarotenze, adapalene, vitamin A acid gel, epiduo, acitetrin, etc.