Is there truly no antidote for Botox?

Question

Is there truly no antidote for Botox? What would a kardashian do if they had bad Botox? What about Pyridostigmine taken orally to contract the muscles. Some docs have been talking about it lately on real self. I know there is an injectable in the works coming out to counteract the affects. I have terrible cheek ptosis and eye bags after Botox and it's causing severe depression (working with psych too). It's been 2.5 months. I know It would be up to 6. Desperate for relief.

Camille Cash, MD · Answer

It may be helpful to understand how Botox works to better understand what you are experiencing.  Botox gradually will be metabolized three to four months after injection for many patients.  If you are noticing that you are able to animate the areas that were treated you can be comfortable that the product is beginning to wear off.  It's always important to select an experienced injector.  Discuss your treatment goals as well as review before/after photos of their work.  I've included a video on neuromodulators that I hope you find helpful.

Sheryl D. Clark, MD, FAAD · Answer

Hello mwashingtondc:

The nerve endings die back after Botox attaches to the SNAP-25 receptors in the nerve terminals, and function returns when new nerve endings grow. Thus can never happen immediately. However, radiofrequency treatments like ThermiSmooth or Pellevé seem to hasten the process.

I know this was not the answer you were hoping for, but it should be helpful. Feel free to reach out with any additional questions.

All the best from New York City, 
Sheryl Clark MD, FAAD.

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