Can Radiesse cause an autoimmune reaction in an area other than where it was injected?

No, it is unlikely that Radiesse injected to your leg is causing the acne on your face. However, this is difficult to answer without pictures. I suggest getting a formal evaluation with a cosmetic dermatologist. Acne requires a combination approach to get long term improvement. I recommend a combination of Cosmelan, salt facials, peels, lasers, microneedling/prp, blue light, radiofrequency and isotretinoin.  Best, Dr. Emer

Radiesse is biodegradable substance chemically identical to bone though it is synthetically made.  It would be unlikely to cause any systemic reaction as it remains where it is placed and is non allergic.

Radiesse cannot cause any tyoe of autoimmune disease no matter where it is injected and neither is the acne issue related