Is it safe to apply Retin A (tretinoin) mixed with moisturizer on my upper and lower eyelids?

Question

Instead of using expensive eye wrinkle creams, I was hoping to start using Retin A (tretinoin) mixed with moisturizer on my upper and lower eyelids. I would start out only a couple nights per week (as tolerated) and be careful not to get in eyes. Is it safe to use tretinoin mixed with moisturizer on my upper and lower eyelids? I was concerned that the tretinoin could soak through the thin eyelid skin and cause eye damage, blindness, or other eye issues.

Raffy Karamanoukian, MD, FACS · Answer

Moisturizers can help with tolerance when using Retin A. In our office, we recommend a ceramide containing moisturizer (Elevase Moisture Booster) to support the skin and help with dryness. Best, Dr. Karamanoukian Los Angeles

Bram Kaufman, MD · Answer

I would not recommend using Retin-A in this fashion. The eyelid skin is too fragile and thin. Talk to your plastic surgeon about alternative, of which there are many.

Medical Relations - SkinCeuticals · Answer

We do not advise mixing Retin-A with your moisturizer and applying on your upper and lower eyelid. For under eye cream, we suggest looking for a product formulated for the delicate eye area with a potent combination of proxylane, blueberry extract, and a complex of flavonoids and synergistic peptides. These can be found in SkinCeuticals A.G.E Eye Complex, a multi-dimensional eye treatment formulated to improve the appearance of dark circles, wrinkles, puffiness, and crepey skin caused by glycation. Glycation occurs when excess sugar molecules bind to collagen and elastin fibers and weaken the skin’s underlying support structure. This rich, dry-finish balm immediately boosts eye-area radiance while visibly improving firmness and elasticity for a more well-rested appearance. In a 12-week study, A.G.E. Eye Complex significantly improved the appearance of key visible signs of aging.

F. Victor Rueckl, MD (in memoriam) · Answer

No. This is not a good idea. Eyelid skin is the thinnest of the body and Retin-A is far too strong for this area and can cause many issues. "This answer has been solicited without seeing this patient and
cannot be held as true medical advice, but only opinion. Seek in-person
treatment with a trained medical professional for appropriate care."

Is it safe to apply Retin A (tretinoin) mixed with moisturizer on my upper and lower eyelids?

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