Thank you for your question. Retin A (also known by its generic name, tretinoin) is a potent derivative of vitamin A. Although it was initially discovered as an acne medication, tretinoin is highly effective as a collagen stimulator. There really is no other topical agent out there with more scientific studies supporting its efficacy in terms of reducing fine lines and wrinkles - tretinoin truly is the gold standard of anti-aging. Tretinoin can be a little irritating when you first start using it - its not uncommon to experience some redness, peeling, and sun sensitivity. Tretinoin is only available by prescription - there are milder, over the counter vitamin A creams (known as retinols) that are available without a doctor's prescription. Glycolic acid is a chemical exfoliant - it essentially works by gently removing the top layers of dead cells from the surface of the skin. Glycolic acid does have mild anti-aging properties as well, and regular use does help your other skincare topicals better penetrate your skin. I would recommend discussing your skincare concerns with a board-certified dermatologist to determine the best regimen for you. Best of luck!