Although most of Botox is bound to the nerve endings within the first hour to two of injection, I prefer to wait for two weeks after the Botox injection before doing laser procedures. The full effects of Botox are seen at approximately 2 weeks. The choice of what needs to be done with the laser may be affected by what the final results are.
Generally it is recommended to not lie down or have your head below your heart/ bend over for 3-4 hours after having botox. The concern is having the botox migrate from the area it was placed. If that does happen you can end up with a droopy eyelid or asymmetrical response in your botox treatment. It is usually okay to have the fractional treatment first, then botox following. The only reason you may not want to do that is if you are going to have swelling from the fractional treatment, this too can cause the botox to migrate. It is always best to discuss this with your treating physician