Latisse is good until at least the expiration date whether or not the bottle has been opened. Storing it in the refrigerator will not increase its shelf life so you might as well keep it in a handier place so you will remember to use it every day. Many medications are actually still quite effective long after their expiration date. The dates are usually there because of FDA requirements. If you're using a product after its expiration date and it seems to have less effect then it's time to replace it. Other risks, such as infection, would be very unlikely. Latisse can be purchased on line from any state in the US with free shipping by going to TheWebDermatologist.com or by following the link below and filling out a short medical history form.