When there is permanent or implanted pigment in the eyelids, this will not have any influence on the effectiveness of Latisse so long as the lash follicles have not been damaged. In general the follicles are much deeper than the pigment and therefore will not be injured by the pigment that was applied. If one has not had permanent eyeliner, it is recommended to try Latisse first since the benefits may be so marked that there will be no need for a permanent eyeliner. In addition to making the lashes darker, thicker, and longer, the Latisse will increase the pigmentation at the base of the lashes to further enhance the effect. Although this is not a permanent effect, it will last so long as a maintenence dose of Latisse is applied a few times per week.