Thank you for inquiring about tretinoin/retin-a. Here are some tips on proper usage. If you have questions and concerns it is alwasy best to see your dermatologist. Apply the tretinoin to face at night at least 20 to 30 minutes after washing your face or 30 minutes after applying your last acne medication. Use a gentle cleanser. Do not spot treat, apply a thin layer (i.e. pea sized amount for entire face) and gently rub into area. Moisturizers and sunscreens are applied in the morning. Never apply any moisturizers, sunscreens or topical medications before, during or after applying the prescribed medication unless instructed otherwise. Side effects: Sun sensitivity. Apply a sunscreen with spf 15 or above at least 15 minutes before going outside. During the early weeks your skin may become worse. This means the tretinoin/retin-a is working. It is normal for some people to experience some irritation (i.e. redness, peeling, stinging, burning and itching) If skin becomes very irritated, decrease usage to every other night or twice a week, gradually building up until you can tolerate every night. Avoid defoliants, scrubs, toners and astringents. I hope this helps. Remember, schedule appointments with your board certified dermatologist for proper skin regimans.