Is Juvederm sourced from humans, animal, or synthetic DNA?

Question

Does the source of Juvederm come from live humans or dead humans? I understand that Juvederm is naturally occurring; and that injections of hyaluronic acid (such as Juvederm) are intended to temporarily replace loss through the normal aging process (thereby, reducing appearance of wrinkles etc). However, where does the source of the Juvederm used in these injections come from? Dead or live donor humans, synthetic reproduction or animal DNA? I need full disclosure to enable an informed decision to proceed with this treatment. Thank you for your consideration.

Ron Shelton, MD · Answer

Juvederm is not a collagen, and it is not derived from animal hides, or any animal parts. In the laboratory, DNA is altered in such away that a bacteria reproduces the DNA suitable to reproduction.

Gregory Turowski, MD, PhD, FACS · Answer

Juvederm is a smooth consistency gel made of hyaluronic acid, a natural complex sugar found in the human skin and throughout the body. It creates volume, hydration, and elasticity. Since the hyaluronic acid in Juvederm is created by biosynthesis in laboratory, patients are not required to take an allergy test before receiving treatment. This dermal FDA-approved filler is used for the wrinkle correction and lip enhancement.

Lorrie Klein, MD · Answer

Juvederm is considered "non-animal based" because it is produced in a lab by a special strain of bacteria specifically created to make a pure hyaluronic acid with all the specifications required. An older product called Hylaform is animal based, and came from roosters.

Otto Joseph Placik, MD · Answer

According to the package insert: "JUV&Eacute;DERM&trade; Ultra injectable gel consists ofcrosslinked hyaluronic acid (HA) produced by Streptococcusequi bacteria." This is essentially though recombinant DNA technology.

Steven Wallach, MD · Answer

Juvederm is a laboratory produced hyaluronic acid which is a great product for facial enhancement.  I use it all the time.

Sigmund L. Sattenspiel, MD · Answer

Juvederm does not come from human material, dead or alive. It is produced in a laboratory by cross-linking hyaluronic acid produced by Streptococcus Equi. Recombinant DNA technology is employed in the manufacturing process. The bacteria that produces the hyaluronic acid is not disease producing. The bottom line is that Juvederm has been shown t to be safe and effective.

Cory Torgerson, MD, PhD, FRCSC - Account Suspended · Answer

The Juvéderm product line is well-known for its smooth consistency that results in a natural feeling and look.Juvéderm is safe and effective, and it is not made from dead or live human beings.  You're right that hyaluronic acid is a naturally occurring substance in human skin, but Juvéderm fillers are made of non-animal stabilized hyaluronic acid created in laboratories from bacterial cultures (harmless streptococcus equi).

Arnold R. Oppenheim, MD (retired) · Answer

The source of the hyaluronic acid to make Juvederm does not come from a human source at all; alive or dead. It is obtained from the bacteria Streptococcus Equi. As you can see from its name, this bacteria is more commonly found in horses. 
This particular bacteria, a harmless one, was chosen since it has the capability of producing copious amounts of hyaluronic acid.

Is Juvederm sourced from humans, animal, or synthetic DNA?

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