Your immune system is already dealing with confused messages. Adding any chemical message signals to your system with Botox or injected neuroproteins is not advised. Your health comes first.Yet, I suspect you must be feeling like you want to do something. There really aren't any topicals you can use that are effective at reducing muscle contraction, but there is an "old school" tape product called Frownies. These are used by wetting and pasting one over the wrinkled area each night to theoretically prevent unconscious frowning.You might find they give you a bit of effect. Just be sure to cleanse the area well when you remove them so you don't create clogged pores. The glue they use should be fairly safe on a any skin. Follow the directions and if you get any skin reaction, don't continue the use.Sometimes massage is a good way to remind your frowning muscles to relax, as is biofeedback that you can do on your own anytime.I have one friend who wears a watch with a blue paper dot on the watch face as a reminder to relax. It seems to help.