How Much Hyaluronidase Needed to Dissolve Juvederm in Tear Trough?

    0.15 cc in a dilution of 150 units/ml would be 22.5 U.  This may be a reasonable starting dose.  Some use 50 U as a starting dose.

Dear alenka21


The simple answer: enough to dissolve what you want

You can see the results pretty quickly

If you are unhappy, go back to your injector and ask for the hyaluronidase, just be sure you want it dissolved


Best regards,

Nima Shemiani

It depends on the amount of product to break down and the desired effect. Could be equal or less. It is variable and ultimately takes a very small amount to do the job.  .015 ML of Juvederm is a very small amount!  Other than the obvious bruise It's hard to tell from your photos exactly where the product was placed. It's probably best to let your provider make that decision. 

It really depends on the amount of filler in the area and how much you are looking to dissolve. Most surgeons will use between 0.1cc to 0.3cc. The enzyme starts to work pretty fast. If you are looking to dissolve some filler because of asymmetry or you just don't like it, then a conservative amount is preferred first and you can always do more if you want more. On the other hand, if this is an emergency, meaning you had an arterial injection and your skin is getting compromised, I would use a high dose immediately (0.3cc) to start.Hope this was helpful. Good luck! 

A highly trained and experienced injector such as a dermatologist will know based on how much filler has been put in, how much hyaluronidase is required. ~ Dr. Benjamin Barankin, Toronto Dermatology Centre.

Quite frankly, a very small amount. Are you positive you are right about the injection amounts of the Juvederm? That would be less than enough to fill a tiny pinpoint scar, and definitely not enough to do a darn thing under the eyes or cause bruising like you have. Are you sure you don't mean you had 1.5cc, and .75cc on each side? This would be much more realistic. The amount of hyaluronidase isn't a lot, but it will depend on how much was injected of the actual filler. And you really need to clarify that part! But any good injector should be able to determine how much hyaluronidase to inject.