If You Use Hyaluronidase to Dissolve a Juvederm Lump, Does It Only Dissolve the Lump or Does It Travel and Undo Everything?

Filler migration, swelling, and granulomas can cause significant discomfort and cosmetic ramifications. Our office specializes in the use of enzymes and filler reversal techniques without hyaluronidase to help improve the results of botched cosmetic fillers, whether caused by Juvederm, Restylane, or foreign fillers. Our plastic surgery institute provides expertise in filler removal. We begin by examining the facial fillers and assessing the likelihood of fluctuance or liquid volumization. If appropriate, we use Hylenex, or other filler reversal agents to reduce swelling and filler migration. Hylenex can be targeted into the areas of concern using multiple layered injection techniques. If the filler does not completely resolve, then additional concentrations may be employed. The technique has the potential to reduce the filler and may slightly impact normal hyaluronic acid. Treatments are repeated and results can improve immediately and with time.

Best,
Dr. Karamanoukian
Realself100 Surgeon

Hyaluronidase is an enzyme that eats up the hyaluronic acid (HA)of whichever HA based filler used. It will only degrade the HA product. Hope this helps. Best of luck! -Dr. Boris

The answer depends upon the amount of hyaluronidase used. Hyaluronidase does have a tendency to spread but if an appropriate dose is injected, the effect should be limited to the area that appears objectionable. I hope this information is helpful.

Stephen Weber MD, FACS

Lone Tree Facial Plastic Surgeon

Hyaluronidase is an enzyme that will dissolve hyaluronic acid, synthetic or natural, so it can reduce swellings associated with any type of hyaluronic filler such as Juvederm or Restylane and your own natural hyaluronic acid, which is part of your dermal tissue.It has a wide safety range but needs to be injected by an expert as it is non-selective.

Hyluronidase certainly works to dissolve Juvederm etc.  Once injected it takes out a whole area of Juvederm and is very hard to control.  But it does work.   This drug needs to be fresh and in date to work, but when it is fresh it takes out ALL.   My Best....Dr C