Long irregular line up the center of the forehead visible at certain angles? (Photo)

It sounds like you might be referring to asymmetry or wrinkles in the forehead area. If Botox and laser treatments haven't provided the results you're looking for, there are a few other options you might consider:
1. Dermal Fillers: These are injectable substances used to plump up skin, fill in lines and wrinkles, help in contouring, and revitalize the face. They are often used in the forehead area to smooth out lines and restore volume.
2. Microneedling: This procedure uses small needles to prick the skin. The purpose of the treatment is to generate new collagen and skin tissue for smoother, firmer, more toned skin. It is often used in conjunction with platelet-rich plasma (PRP) or serums to enhance the effects.
3. Radiofrequency treatments: These treatments use energy to heat the dermis and stimulate collagen production, which can help to reduce the appearance of lines and wrinkles.
4. Ultherapy: This is a non-invasive procedure that uses ultrasound energy to lift and tighten the skin.
5. Surgical options: In some cases, a brow lift or forehead lift might be recommended to correct more significant asymmetries or sagging.
It's important to consult with a dermatologist or plastic surgeon to discuss these options and determine the best course of treatment for your specific needs. Please note that results can vary and multiple treatments may be necessary to achieve the desired outcome.

Quite simply, the underlying muscles of facial expression are responsible for the wrinkling in the first place. With time, the overlying skin becomes creased and indented. So, to properly treat these kinds of issues, the Botox is used to quiet the activity (but not freeze) the underlying trouble-making muscles and then a cohesive, malleable, low viscosity filler can be used to treat the static creases. The latter in particular, in areas such as the glabella and forehead, are treatment regions that should not be left to the hands of novice, inexperienced filler injectors accustomed to using simple Restylane or plain Juvederm for ordinary smile lines. Make sure to consult with an experienced, board certified cosmetic dermatologist. Best of luck.