Little Hole in the Lips After Juvederm Injections

Hyaluronidase is ok to use, and will not dissolve your natural tissue.  I am not sure what you mean by holes.  When I look at the upper lip in this photos, I see the line is uneven, a bit wavy.  If that is what you are referring to, and you are sure it wasn't like that when you started, then I would recommend some hyaluronidase to get any residual product out.  Three years is a long time to still have the product there, but it is not impossible.  In the future, I would not recommend putting that much product in the lip as it tends to look too unnatural.

Wow - two vials for your upper lip.  That is a lot of product.  Most of the product should be dissolved by now.  You can try to use hyaluronidase to dissove any residual product but you should know that you still may have residual asymmetry.  I'm not sure what you mean by holes in your upper lip - I don't see that in your photo.  Regardless, I you should see a plastic surgeon or board-certified dermatologist to evaluate your individual anatomy and help make some recommendations to give you the look you want.

Dr. Cat Begovic M.D.

It would not be unusual for somel of the material to dissolve at a slightly different rate. Three years is  a long time  for this to last but anything possible. Hyaluronidase will dissolve what is left, if any. It will not hurt your lip. Maybe you should consider putting a little less in at a time as you might want to boost your volume after months and should have a smoother transition as it disappears.