Which works best for lines around the mouth – Restylane or Juvederm?

The answer to the question is not as simple as it may seem on the surface. It presumes that the aesthetic problems around the mouth only require treatment with a filler and that it is simply a matter of choosing between two of the most commonly known fillers, i.e. Juvederm and Restylane and making a cost comparision between treating physicians. Without knowing the specifics or at least a photo to examine, it is impossible to determine which therapy(ies) are appropriate in this situation.In general terms, however, the mouth unit, is an extremely important aesthetic region of the face, probably second only to the eye unit in its contribution to our overall look and youthful appearance. The mouth unit consists of the red lips themselves, and the white areas around them, which include the philtrum, Cupid's Bow, and the vertical  "lipstick bleeding" lines  (aka "smoker's" lines) and the droopy, so-called "marionette" lines at the angles of the mouth.If in this case, the "lines around the mouth" referred to here are the vertical lipstick bleeding lines, then a combination of a neuromodulator (such as Botox) to diminish the muscular contribution to their formation and a filler, such as Belotero Balance instilled very superficially within the lines themselves to raise and straighten them would be the most appropriate approach. Belotero Balance has not been associated with the bluish skin discoloration that can sometimes be seen when either Restylane or Juvederm when injected superficially. The combination of neuromodulator and filler has been shown to sometimes significantly increase the longevity of the cosmetic result.If on the other hand, the marionette lines at the corners of the mouth are the problem, neither Restylane nor Juvederm, both fillers best reserved for treating more shallow lines and wrinkles, would be appropriate. More robust volumizing fillers, would be more appropriate. Radiesse, a calcium-based product or Voluma, make better choices, or even Perlane L, a member of the Restylane family of products known for its lifting capacity and volumizing capabilities. The point is that there is no substitute for consultation with a board certified aethetic core physician with extensive experience with all available modalities who can tailor a treatment plan specifically for you.

Juvederm and Restylane are both FDA approved hyaluronic acid fillers, The difference in these two fillers is the concentration, thickness, and the company made by each one. I suggest you consult with your medical provider and see what filler he/she recommends 

There are many studies out there that show that one lasts longer than the other, and then others that refute those claim, so it depends which study you are reading and if you are talking about Juvederm Ultra or Ultra Plus.