There is no good science available to support an answer on this topic, only common sense. It seems reasonable to limit the type of exercise that elevates cardiac output, potentially washing out some of the Botox that has been injected before it has a chance to work. Massage afterwards may increase the spread of Botox and changes in body position might also allow the diffusion of Botox, Dysport or Xeomin into adjacent muscles. These are all reasonable but unproven concerns. I had the chance to ask these same questions to a few expert scientists not too long ago. They didn't know the answers, largely because it is extremely difficult to measure how long it takes a toxin such as Botox to enter the nerve cell. Practically speaking, many of my patients do exercise afterwards and I have seen no adverse effects.