Theoretically, you want the inflammatory process to continue as long as possible and you don't want to inhibit the process. Part of how the treatment works is through the inflammatory process itself. Any non-steroidal and steroidal type medication will decrease inflammation. That said, the time period that is most important to promote that inflammatory response is immediately after the procedure during the 2 minute massage. If you are experiencing discomfort, try other modalities such as applying compression garments such as Spanx. If you are a few days out, a few doses of an NSAID will not likely have any affect. And of course, if you have concerns, you should contact your provider. Make sure your CoolSculpting practice is certified.