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Thank you for your question. Unfortunately, Accutane does not have an effect on hormones, so it will not help with breakouts prior to your menstrual cycles. Alternative treatment options such as oral contraceptives (also known as birth control) or Spironolactone can help with hormonal acne. I highly recommend you consult with a board certified dermatologist regarding your acne and to discuss treatment options that best suit your needs. Take care and good luck.