Deep wrinkles on the forehead do require multiple treatment modalities. I would first start off with Botox, maximizing the amount on the forehead. Botox , or even Dysport, will relax the muscles and smooth out the lines, however they will not completely eliminate them. After 2 weeks, I will re-evaluate again. I love the fractional CO2 laser and I typically do it 2 weeks after Botox injection. The CO2 will help but do not completely remove the lines either. 6 weeks after the fractional CO2, I re-evaluate again. Sometimes, I repeat the fractional CO2 (touch-up) or at this point consider adding Juvederm to the area. Out of all the treatment mentioned above, the CO2 is the one with the longest lasting results. Its important to emphasize that if you want to get a fractional co2 for the creases, I would strongly advice Botox 2 weeks prior to the procedure. Your final results will be much improved. Dr Behnam, Santa Monica.